Immunohistochemical Characteristics of Kaposi Sarcoma and its Mimicries.
- Author:
Kyoung Bun LEE
1
;
Hye Seung LEE
;
Hee Eun LEE
;
So Yeon PARK
;
Jin Haeng CHUNG
;
Gheeyoung CHOE
;
Woo Ho KIM
;
Kye Yong SONG
Author Information
1. Department of Pathology, Seoul National University College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Sarcoma, Kaposi;
Herpesvirus 8, human;
Latent nuclear antigen;
Monoclonal antibody D2-40;
Immunohistochemistry
- MeSH:
Diagnosis, Differential;
Factor VIII;
Hemangioendothelioma;
Hemangiosarcoma;
Herpesvirus 8, Human;
Immunohistochemistry;
Sarcoma, Kaposi*;
Vimentin
- From:Korean Journal of Pathology
2006;40(5):361-367
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: The differential diagnosis of Kaposi sarcoma includes many disease that range from benign disease to malignant tumors. However, little information is available about the immunohistochemical characteristics of Kaposi sarcoma. METHODS: The expressions of 13 various proteins (HHV-8 LNA-1, Ki-67, bcl-2, p53, CD31, CD34, factor VIII, D2-40, vimentin, SMA, S-100, EMA, and c-kit) were evaluated immunohistochemically in 49 vascular tumors including 16 Kaposi sarcomas, 8 angiosarcomas, 2 hemangioendotheliomas, and 23 benign vascular tumors with using the tissue array method. RESULTS: All 16 cases of Kaposi sarcoma showed nuclear staining for HHV-8 LNA-1, whereas all the cases of angiosarcoma and benign vascular lesions were negative for HHV-8 LNA-1 (p<0.001). All Kaposi sarcoma were positive for D2-40, which is a marker of lymphatic differentiation, but 25% of the benign vascular lesions and 30.4% of the angiosarcoma were positive for D2-40 (p<0.001). The mean proliferation index as assessed by Ki-67 immunostaining revealed no difference between the benign and malignant vascular lesions (p>0.05). No Kaposi sarcoma showed a bcl-2 expression, but 62.5% of the angiosarcomas and 21.7% of the benign vascular tumors had bcl-2 expressions (p=0.005). CONCLUSIONS: Immunohistochemical detection of HHV-8 LNA-1 and D2-40 are useful tools to differentiate Kaposi sarcoma from other vascular tumors.
