Quantitative evaluation of salivary gland dysfunction after radioiodine therapy using salivary gland scintigraphy

VernacularTitle:定量唾液腺显像评价放射性碘治疗后唾液腺功能
Author: Bofeng ZHAO ; Mingzhi PAN ; Yuanming HU ; Wei WEI ; Zonggui XIE
Publication Type:Journal Article
Keywords: Thyroid neoplasms; Iodine radioisotopes; Salivary gland
From: Chinese Journal of Primary Medicine and Pharmacy 2011;18(22):3041-3043
CountryChina
Language:Chinese
Abstract: Objective To assess the variation of salivary gland function in differentiated thyroid carcinoma (DTC) patients receiving different doses of 131 I therapy in the first.Methods 40 DTC patients were divided into two groups according to the application 131I doses,salivary scintigraphy was performed with 99TcmO4-on DTC patients before and 3months after 131 I therapy.Quantitative analysis of salivary gland function were performed.Results In low dose group,only the uptake ratio of 30min (UR30) of bilateral parotid decreased ( P ＜ 0.05 ) ; but in high - dose group,the uptake ratio of 30min (UR30),excretion fraction ( EF ),excretion rate (ER) of bilateral parotid and submandibular glands were significantly decreased,excretion time(EP) significantly prolonged after 131 I therapy( all P ＜0.05) ;the parotid gland was more severely than the submandibular gland.Conclusion Salivary gland function was damaged of DTC patients receiving different doses of 131I therapy in the first,salivary gland dysfunction correlated well with the administered dose.