Clinical analysis of mycophenolate mofetil combined with prednisone in treatment of old patients with refractory nephrotic syndrome
10.3760/cma.j.issn.1673-4904.2011.31.011
- VernacularTitle:吗替麦考酚酯联合泼尼松治疗老年难治性肾病综合征的临床分析
- Author:
Haiying HAO
;
Zhaoxia ZHENG
;
Lan XU
- Publication Type:Journal Article
- Keywords:
Prednisone;
Nephrotic syndrome;
Aged;
Mycophenolate mofetil
- From:
Chinese Journal of Postgraduates of Medicine
2011;34(31):29-31
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect ofmycophenolate mofetil combined with prednisone in treatment of old patients with refractory nephrotic syndrome.Methods From June 2009 to June 2010,67cases of old patients with refractory nephrotic syndrome were divided into two groups by random digits table,32 cases in control group were treated with cyclophosphamide combined with prednisone and 35 cases in observation group were treated with mycophenolate mofetil combined with predrisone.The clinical effect and the levels of urinary protein,serum creatinine and serum uric acid between two groups were compared.Results There was no significant difference in total effective rate between two groups [68.8％(22/32) vs.74.3％ (26/35)] (P ＞ 0.05 ).After treatment,the levels of urinary protein,serum creatinine and serum uric acid in two groups were decreased (P＜ 0.05 ),but there were no significant differences between two groups (P ＞ 0.05 ).The adverse reaction rate in observation group was significantly lower than that in control group (P ＜ 0.05).Conclusion Mycophenolate mofetil combined with prednisone in treatment of old patients with refractory nephrotic syndrome has good effect and low adverse reaction,and it can be applied in clinic.
