Mycophenolate mofetil combined with low dose of hormone and lamivudine in the treatment of hepatitis B virus associated glomerulonephritis
10.3760/cma.j.issn.1673-4904.2011.31.001
- VernacularTitle:吗替麦考酚酯、小剂量激素、拉米夫定联合治疗乙型肝炎病毒相关性肾炎
- Author:
Chengmin CAI
;
Lin WEI
;
Zhixin DUAN
;
Wei WU
;
Haitao ZONG
- Publication Type:Journal Article
- Keywords:
Glucocorticoids;
Lamivudine;
Mycophenolate mofetil;
Hepatitis B virus associated glomerulonephritis
- From:
Chinese Journal of Postgraduates of Medicine
2011;34(31):1-4
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the efficacy of mycophenolate mofetil (MMF) combined with low dose of hormone and lamivudine in the treatment of hepatitis B virus associated glomerulonephritis (HBV-GN).Methods The clinical data of 49 HBV-GN patients diagnosed by renal pathology was reviewed.They were treated with MMF( ≥ 12 years old,0.75 g,two times a day; ＜ 12 years old,0.4 g/m2,two times a day),low dose of hormone [0.5 mg/(kg·d) ],lamivudine( ≥ 12 years old,100 mg/d; ＜ 12 years old,3 mg/kg,two times a day).Results Among of 49 HBV-GN patients,clinical cure rate was 71.4％(35/49),the total effective rate was 81.6％(40/49),85.7％(42/49) patients' HBV DNA level decreased from 5.43 ×104 copies/ml to ＜ 1000 copies/ml.The complete remission rate was 88.0％ (22/25),the partial remission rate was 8.0％ (2/25),the inefficiency was 4.0％ (1/25) in membranous nephropathy (MN);the complete remission rate was 44.4％ (4/9),the inefficiency was 55.6％ (5/9) in mesangial proliferative glomerulone phritis (MsPGN) ; the complete remission rate was 70.0％(7/10); the partial remission rate was 30.0％(3/10)in membrane proliferative glomerulone phritis (MPGN) ;the complete remission rate was 40.0％ (2/5),the inefficiency was 60.0％(3/5) in focal segmental glomerulosclerosts (FSGS).There was significant difference among the different pathological type (P＜0.05).There were less adverse reactions.Conclusions MMF combined with low dose hormone and lamivudine is safe and effective in treating HBV-GN.The efficacy and pathological type has some relationship,MN has the best response,MPGN and MsPGN are second,FSGS is poor.
