The risk factors of carotid atherosclerosis in sleep apnea-related hypertension
10.3760/cma.j.issn.0578-1426.2011.12.009
- VernacularTitle:睡眠呼吸暂停相关性高血压颈动脉硬化的危险因素
- Author:
Weiping CHENG
;
Nanfang LI
;
Zhitao YAN
;
Jing HONG
;
Yingchun WANG
;
Tao LI
- Publication Type:Journal Article
- Keywords:
Sleep apnea,obstructive;
Hypertension;
Atherosclerosis
- From:
Chinese Journal of Internal Medicine
2011;50(12):1026-1029
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the risk factors and morbidity of carotid atherosclerosis (CA) and unstable plague in patients with sleep apnea-related hypertension (SA-RH).MethodsA total of 603 SA-RH subjects screened by polysomnography according to apnea hypopnea index (AHI) were recruited and divided into 3 groups:mild (AHI 5-15 ),moderate (AHI 15-30) and severe (AHI ≥ 30) group,with hypertensive patients with AHI less than 5 served as control.CA was determined by doppler ultrasound as formation of plaque and/or intima-media thickness more than 0.9 mm.Unstable atheroma plaque (UAP) was defined as low echo plaque and/or admixing echo plaque.Results Gender,age,BMI and blood pressure were not matched among groups.The prevalence of CA increased in moderate and severe SA-RH than that in control ( P < 0.01 ) with no significant difference for UAP among groups.Factor analysis was performed to extracted common factors that may influence CA and UAP,such as factor 1-6,represent obstructive sleep apnea (OSA),dyslipidemia (TC,LDL),BMI,blood pressure,age and duration of disease and dyslipidemia (TG,HDL) respectively.Logistic analysis show that OSA and dyslipidemia (TC,LDL) increased the risk of CA,with OR 1.36(95% CI 1.15-1.59),1.31 (95% CI 1.12-1.54)respectively,and dyslipidemia (TC,LDL) increased the risk of UAP,with OR 1.30 (95% CI 1.06-1.58).ConclusionsIn SA-RH populations,higher prevalence of CA may be associated with severity of OSA independently,meanwhile the formation of UAP may be mainly associated with dyslipidemia.