Methylation status of CDH13 gene promoter in colon cancer
10.3760/cma.j.issn.1673-4904.2011.32.009
- VernacularTitle:结肠癌患者CDH13基因启动子甲基化状态
- Author:
Liang ZHAO
;
Jianpeng YU
- Publication Type:Journal Article
- Keywords:
Colonic neoplasms;
CDH13;
Methylation-specific polymerase chain reaction
- From:
Chinese Journal of Postgraduates of Medicine
2011;34(32):23-24
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the methylation status of CDH1 3 gene promoter in colon cancer by using methylation-specific polymerase chain reaction(MSP)technique.Method The tissue specimens from 32 cases of colon cancer(observation group),and 12 cases of normal colon tissues(control group)were examined,the methylation of CDH13 gene promoter was detected by MSP.Result The methylation of CDH13 gene promoter was detected in 19 cases(59.4％,19/32)in observation group,1 case(8.3 ％,1 / 12)in control group,there was statistical significance between two groups(P =0.002).Conclusion Frequency of the methylation of CDH13 gene promoter is apparently higher in colon cancer tissues than that in normal colon tissues,it reveals that CDH13 gene promoter may contribute significantly to the development of colon cancer.
