Additive effect of tryptophan hydroxylase 1 and Monoamine oxidase A gene on negative emotional management in depressive frontal subregions
10.3760/cma.j.issn.1674-6554.2011.11.008
- VernacularTitle:色氨酸羟化酶1和单胺氧化酶A基因对抑郁症患者额叶负性情绪加工功能的叠加效应
- Author:
Qijun LI
;
Jing ZHANG
;
Zhijian YAO
;
Haiyan LIU
;
Qing LU
- Publication Type:Journal Article
- Keywords:
Depression;
Frontal lobe;
Functional magnetic resonance imaging;
Serotonin;
Gene
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2011;20(11):983-985
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explore the genetic impact of TPH1 A218C,MAOA-uVNTR on abnormal frontal lobe of depressed patients and the interactions between the two polymorphisms using the method of genetic imaging.Methods28 patients with major depression and 34 healthy controls which were equal in sex,age,years of education and had negative family history of mental illness were recruited in our study.All paticipants underwent functional Magnetic Resonance Imaging (FMRI) in negative emotion recognition and were divided into different genotypes.Then frontal lobe was extracted as region of interest by WFU software into six subregions-bilateral superior frontal lobe,middle frontal lobe and inferior frontal lobe.ResultsPatients (0.19 ± 0.01 ) and controls (0.15± 0.05 ) with TPH1 AA genotype showed increased activation in left inferior frontal lobe than patients and controls with AC or CC genot.Patients with AA genotype showed increased activation in right inferior frontal gyrus(0.28 ±0.07) than other five groups as well.Patients with MAOA-H genotype showed increased activation in right middle frontal gyrus(0.15 ±0.06),left inferior frontal gyrus(0.18±0.02) than patients and controls with L genotype.Superimposition of TPH1 A218C and MAOA-uVNTR exsited in abnormal function of left inferior frontal gyrus(F=4.98,P =0.047 ).Patients with AA and H genotype showed increased activation in this area significantly than other patient group.ConclusionDifferent genes in serotonin system can affect brain function through a common 5-HT feature.
