Association study between schizophrenia and polymorphism of phosphoserine aminotransferase 1gene
10.3760/cma.j.issn.1674-6554.2011.11.019
- VernacularTitle:磷酸丝氨酸氨基转移酶1基因多态性与精神分裂症的关联研究
- Author:
Juan GUO
;
Yuantang CHEN
;
Changjiang HE
;
Li ZHANG
;
Yu WU
;
Yangling XING
;
Lei AO
;
Xiang CHEN
- Publication Type:Journal Article
- Keywords:
Schizophrenia;
Phosphoserine aminotransferase 1;
Polymorphism;
Association analysis
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2011;20(11):1019-1021
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo detect the association between schizophrenia and polymorphism of phosphoserine aminotransferase 1 ( PSAT1 ) gene.MethodsThe study group included 158 patients with schizophrenia from Xi' an Mental Health Center and the control group included 316 parents.The polymorphism of rs69287125,rs137824326 of phosphoserine aminotransferase 1 gene was detected with PCR methods and SNP typing in all nucleus families by correlation analysis and haplotype relative risk analysis.ResultsThe rs69287125 allele was associated with schizophrenia (P=0.011 ),the G allele was protective factor (Z =-2.31 ) and the A allele was hazarding factor (Z =2.31 ).The rs137824326 allele was associated with schizophrenia (P=0.007 ),the G allele was protective factor ( Z =- 2.54) and the A allele was the hazarding factor( Z =2.54).The haplotypes of A/A and G/G in the rs69287125-rs137824326 were associated with schizophrenia (P =0.021,0.015,Z =2.16,- 1.85).ConclusionThe polymorphism of phosphoserine aminotransferase 1 gene is associated with schizophrenia in Chinese.
