Relationship of leptin-to-adiponectin ratio with cardio ankle vascular index in maintenance hemodialysis patients
10.3760/cma.j.issn.1008-6315:2011.11.007
- VernacularTitle:维持性血液透析患者心踝血管指数与血清瘦素和脂联素比值的相关性
- Author:
Yinna WANG
;
Yi SUN
;
Ying WANG
;
Yanli JIA
- Publication Type:Journal Article
- Keywords:
Leptin;
Adiponectin;
Cardio ankle vascular index;
Maintenance hemodialysis;
Atheroselerosis
- From:
Clinical Medicine of China
2011;27(11):1141-1144
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association of serum leptin(LEP),adiponectin(ADPN)and leptin-to-adiponectin(L/A)ratio with cardio ankle vascular index(CAVI)in the patients maintaining hemodialysis(MHD).Methods Sixty MHD patients and thirty healthy volunteers were involved in the study.The levels of LEP and ADPN were determined by ELISA.Atherosclerosis was evaluated by the cardio ankle vascular index which was measured by using a VaSera VS-1000 machine.Results The levels of serum LEP and ADPN in hemodialysis patients were significantly higher than those in healthy controls([7.99 ± 1.21]μg/L vs.[4.18 ± 1.10]pg/L)and([15.12 ± 4.68]mg/L vs.[8.58 ± 2.23]mg/L),respectively,P ＜ 0.01].With the progression of atherosclerosis,the levels of serum LEP increased significantly,while the levels of serum ADPN decreased significantly.The L/A ratio was dramatically increased in patients with atherosclerosis.Multiple stepwise regression analysis showed that independent risk factors associated with CAVI include age,diabetes,levels of LEP and L/A ratio.Conclusion The increased serum LEP level and decreased serum ADPN level may be involved in the progression of atherosclerosis in MHD patients.The L/A ratio may be a powerful independentpredictor for CAVI in MHD patients.
