Clinical curative effects of angiotensin Ⅱ 1 receptor blocker in treating primary hypertension and its effects on insulin sensitivity
10.3760/cma.j.issn.1673-4904.2011.31.010
- VernacularTitle:血管紧张素Ⅱ1型受体阻断剂治疗原发性高血压的临床疗效及其对胰岛素敏感性的影响
- Author:
Lianghao XIANG
;
Xing WU
- Publication Type:Journal Article
- Keywords:
Amlodipine;
Angiotensin Ⅱ 1 receptor blocker;
Primary hypertension;
Insulin resistance;
Telmisartan
- From:
Chinese Journal of Postgraduates of Medicine
2011;34(31):26-28
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical curative effects of angiotensin Ⅱ 1 receptor blocker in treating primary hypertension and its effects on insulin sensitivity.Methods Eighty primary hypertension patients were divided into the treatment group ( 40 cases,treated with telmisartan ) and the control group (40cases,treated with amlodipine) by random digits table.The treatment period was 8 weeks.After treatment,the clinical curative effect and insulin sensitivity was compared between the two groups.Results In treatment group and control group,the total effective rate was 75.0%(30/40) and 72.5%(29/40),there was no significant difference (P> 0.05 ).Before treatment,the insulin sensitivity index ( ISI ) in treatment group and control group was -4.5 ±0.8 and -4.7 ±0.7 (P > 0.05),after treatment,the ISI was -3.2 ±0.5 and -4.4 ±0.6 (P<0.05).Conclusion The clinical curative effects of angiotensin Ⅱ 1 receptor blocker in treating primary hypertension are obvious,and may improve the insulin sensitivity.