Liver transplantation between a RhD positive graft to a RhD negative recipient
10.3760/cma.j.issn.1007-8118.2011.11.011
- VernacularTitle:RhD阴性患者接受RhD阳性供肝移植
- Author:
Genshu WANG
;
Hua LI
;
Jian ZHANG
;
Nan JIANG
;
Guoying WANG
;
Binsheng FU
;
Yang YANG
;
Guihua CHEN
- Publication Type:Journal Article
- Keywords:
RhD negative recipient;
Liver transplantation;
Immunosuppressant regimen
- From:
Chinese Journal of Hepatobiliary Surgery
2011;17(11):905-908
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the choice of graft,and transfusion and immunosuppressant regimen of a RhD negative recipient in liver transplantation.MethodsOne RhD negative patient with hepatocellular carcinoma who received a liver graft from a RhD positive donor was retrospectively studied,and related references were reviewed.During the operation,the patient received five units of RhD negative/O RBC,3000 ml positive/O plasma and 30 units cryoprecipitate.Tacrolimus and prednisone were used to prevent rejection,and prednisone was withdrawn 30d post transplant.Results The patient's liver function recovered smoothly,without any acute rejection or hemolytic reaction.Anti-D antibody was not detected.The patient suffered from cancer recurrence 9 months and died of brain metastasis 13 months after transplantation.ConclusionsA RhD negative recipient can receive a graft from a RhD positive donor in liver transplantation.The selection of RBC and platelet from RhD negative or positive donors should be based on the result of anti-D antibody test.Plasma and cryoprecipitate can be transfused regardless of Rh type.Enhanced immunosuppressant regimen was unnecessary for these patients.
