Transplantation of bone marrow mesenchymal stem cells in rat model of Tourette syndrome

VernacularTitle:骨髓间充质干细胞移植治疗Tourette综合征大鼠实验研究
Author: Xiumei LIU ; Qing CHU ; Mingji YI
Publication Type:Journal Article
Keywords: Mesenchymal stem cells; Transplantation; Tourette syndrome; Stereotypy
From: Chinese Journal of Behavioral Medicine and Brain Science 2011;20(11):990-992
CountryChina
Language:Chinese
Abstract: ObjectiveTo investigate the effect of mescenchymal stem cell (MSC) transplantation on Tourette syndrome(TS)model rats.MethodsStereotypies can be successfully induced in rats by intrastriatal microinfusion of TS sera.MSC suspension was bilaterally injected into the striatum.Survival and differentiation of transplanted MSC were tested through immunohistochemical analyses.ResultsFlow cytometry results demonstrated that the cells strongly expressed CD29(95.2％ ),CD105(97.2％ ),CD44(96.3％ ) and CD106 (94.1％).TS rats with MSC grafts exhibited significantly decreased stereotypic behaviors at 10 and 14 days(95.5 ±6.6,73.1 ± 6.5 vs.114.1 ± 6.0,108.0 ± 6.4).Immunohistochemistry analyses revealed survival of transplanted MSC and differentiation into neurons and astrocytes in the rat brain.ConclusionIntrastriatal transplantation of human MSC can provide therapeutic potential for TS.