A clinical analysis and prognostic study of 187 cases with T1G3 bladder cancer
10.3760/cma.j.issn.1000-6702.2011.11.015
- VernacularTitle:T1G3膀胱癌187例临床分析及预后研究
- Author:
Xiaodong LI
;
Guang SUN
;
Xiaoqiang LIU
;
Shuo LIU
- Publication Type:Journal Article
- Keywords:
Urinary bladder neoplasms;
Carcinoma;
T1G3;
Prognosis;
Survival analysis
- From:
Chinese Journal of Urology
2011;32(11):766-770
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveThe clinical features of T1G3 bladder cancer and the risk factors of the recurrence,progression and death were studied. Methods One hundred and eighty-seven cases with T1G3 bladder cancer were diagnosed from 1998 to 2006 in the Institute of Urology of Tianjin.There were 162 males and 25 females in the study group.The average age was 66 years (35 -92 years).A clinical epidemiology study was carried out and prognosis information was collected.The risk factors were preliminary screened with Kaplan-Meier univariate analysis and then finally determined with multivariate Cox proportional hazards regression model. ResultsBased on a mean follow-up of 46 months (range,12 to 111 months),100 (53.5％) of the cases had a recurrence,61 (32.6％) cases progressed and 37( 19.8％ ) cases died.The 1-,2-,3-,5-year probability of tumor recurrence was 35.0％,60.0％,63.0％,65.0％.The 1-,2-,3-,5-year probability of disease progression was 12.0％,27.0％,34.0％,38.0％ and the 1-,2-,3-,5-year probability of death was 0,11.0％,17.0％,26.0％,respectively.The tumor size,number of tumors,immediately intravesical instillation and the first recurrence time ≤6 months were the risk factors associated with tumor recurrence of T1G3 bladder cancer.The tumor modality,cancer in situ,the first recurrence time ≤ 6 months and frequency of recurrence were the risk factors of disease progression.Only progression was a risk factor of death. ConclusionsTumor of T1G3 bladder cancer patients with features such as the tumor size ≥3 cm,tumor multiplicity,and first recurrence time ≤6 months were more likely to relapse.Immediately intravesical instillation could reduce the risk of recurrence.Cystectomy must be carried out early if the patient with T1G3 bladder cancer has the risk factors of progression such as the nodous tumor,tumor in suit,the first recurrence time ≤6 months and frequency of recurrence ＞ 1.
