Blood and cerebrospinal fluid levels of brain-derived neurotrophic factor in patients with hypertensive cerebral hemorrhage and their correlation with recovery of neurological functions

VernacularTitle:高血压脑出血患者脑源性神经营养因子水平变化及其与神经功能的相关性研究
Author: Shengli CHEN ; Tao GONG ; Changqing LI ; Shuqiong ZHANG ; Li LI
Publication Type:Journal Article
Keywords: Cerebral hemorrhage; Nerve growth factor
From: Chinese Journal of General Practitioners 2011;10(11):821-823
CountryChina
Language:Chinese
Abstract: Brain-derived neurotropic factor (BDNF) contents in blood and cerebrospinal fluid (CSF) were detected by ELISA method in 30 cases of hypertensive cerebral hemorrhage (HCH group) and 30 healthy subjects (control group).The performance and neurological functions of patients were evaluated by National Institutes of Health Stroke Scale( NIHSS),Hamilton Depression Scale ( HAMD),Barthel Index of Daily Living Skills.The result showed that the contents of BDNF in blood and CSF of HCH patients in recovery stage were significantly higher than those in acute stage and those of control group ( P ＜ 0.05 ) ; the contents of BDNF in blood and CSF were negatively correlated with neurological impairment degree ( P ＜0.05).The results suggest that BDNF in the blood or the CSF may promote the recovery of neurological function in patients with hypertensive cerebral hemorrhage.