Lesions of the medial prefrontal cortex of guinea pig inhibit acoustic startle reflex
10.3760/cma.j.issn.1674-6554.2011.10.001
- VernacularTitle:损伤内侧前额叶抑制豚鼠听觉惊吓反射的研究
- Author:
Juan YAO
;
Guangyan WU
;
Langqian ZHANG
;
Xuan LI
;
Zhengli FAN
;
Yi YANG
;
Jianfeng SUI
- Publication Type:Journal Article
- Keywords:
Acoustic startle reflex;
Medial prefrontal cortex;
Guinea pig
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2011;20(10):865-868
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe and analyze the role of different subfields of medial prefrontal cortex (mPFC) in the expression course of startle reflex.Methods 24 healthy male British kind of albino guinea pigs were randomly divided into 4 groups:anterior cingulated cortex lesion ( n =6) and sham-lesion ( n =6) ( Experiment 1 ) ; prelimbic cortex lesion/joint lesion of prelimbic cortex and anterior cingulated cortex(n=6) and sham-lesion ( n =6) ( Experiment 2 ).The animals were injected lidocaine ( lesion ) or physiological saline ( sham-lesion ).Each group received paired training of conditioned stimulus( CS,a tone) and unconditioned stimulus (US,a air puff),to observe the acoustic startle reflex(ASR) change of these groups.Results As the results of experiment 1 suggested,SR rate did not change significantly after anterior cingulated cortex lesion ( time effect:F =15.421,P =0.098 ; group effect:F =14.753,P =0.084).As the results of experiment 2 suggested,SR rate did not change significantly after prelimbic cortex lesion ( time effect:F =14.975,P =0.178 ; group effect:F =18.643,P =0.089).When prelimbic cortex and anterior cingulated cortex were lesioned at the same time,SR rate declined significantly and didn ' t recover with the following training ( group effect:F =67.743,P =0.009 ).ConclusionLesions of the prelimbic cortex and anterior cingulated cortex in mPFC cause the significantly decline of acoustic startle reflex( ASR),which don' t recover with the following training.This study indicates that mPFC involves in the regulation of ASR,but the regulation mechanism needs to be discussed.
