One year follow-up study of urolithiasis in infants exposed to melamine-tainted powdered formula
10.3760/cma.j.issn.1000-6702.2011.11.019
- VernacularTitle:三聚氰胺致婴幼儿泌尿系结石一年随访研究
- Author:
Panfeng SHANG
;
Hong CHANG
;
Zhongjin YUE
;
Wei WANG
;
Qiqi HE
;
Wei SHL
;
Haibin ZHANG
;
Xiaoshuang TANG
;
Jianhua MA
- Publication Type:Journal Article
- Keywords:
Urinary calculi;
Melamine;
Infant;
Follow-up studies
- From:
Chinese Journal of Urology
2011;32(11):781-784
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the condition of infants with urolithiasis caused by melaminetainted powdered formula at one-year follow-up. Methods Eighty-one young children with melamine-induced urolithiasis were followed up,which included urinalysis,renal-function tests,urinary tests for biochemical markers of renal glomerular and tubular function,and ultrasonography.Eighty-one age-matched healthy infants without exposure to melamine-contaminated formulas were enrolled as controls. Results Fifty-one of the patients were male and 30 female,with a mean age of 26 months (range 13 -48 months).The 81 children were divided into 2 groups according to treatment protocols.Group 1 received conservative treatment ( n =54 ) and Group 2 received surgical treatment ( n =27 ).In Group 1,3 patients (5.6％) had stone-residual:1 girl had calculus of 0.4 cm in diameter in the left kidney and 2 girls had calculus of 0.3 cm in diameter in the right kidney.In Group 2,2 patients (7.4％) had stone-residual,1 boy had crystallization of 0.2 cm in diameter in the right kidney and 1 boy had calculus of 1.5 cm in diameter in the left kidney,positive stone was confirmed by X-ray and accepted percutaneous nephrolithotomy.Urinary microalbumin levels were significantly increased in the children with melamine-induced urolithiasis compared with the control group (P ＜0.01 ).Blood urea nitrogen and serum creatinine were within the normal range with no significant difference between the 2 groups. ConclusionsAt one-year follow-up most of the children exposed to melamine-tainted infant formula in both treatment groups had returned to a healthy state,suggesting a satisfactory outcome for both treatment options.However,surgery is recommended in patients with stoneresidual ＞ 10 mm.
