Effects of different prenatal stimulation on fearful behavior of rat offspring
10.3760/cma.j.issn.1674-6554.2011.10.010
- VernacularTitle:孕期不同环境对仔鼠恐惧行为的影响
- Author:
Jing QIAN
;
Yuwei WANG
- Publication Type:Journal Article
- Keywords:
Prenatal stress;
Environmental enrichment;
Behavior;
Open-field test
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2011;20(10):893-895
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of different prenatal stimulation on fearful behavior of offspring.Methods On gestational days 11,primigravid female rats were randomly assigned to three groups:enriched group,stressed group and the control group.Only male offspring were used in the present study.Open field test and the defensive withdrawal test were performed at P25,P45 and P60.Results1.Open-field test:PS offspring at any age had greater central grille time,decreased total cross number and stand number than their corresponding controls (all P ＜ 0.05 ).On the contrary,the prenatal enriched offspring at 25 days of age had increased total cross number ( 101.75 ± 11.87 ;89.13 ± 11.20 ; P ＜ 0.05 ) and shorter central grille time ( ( 1.88 ± 0.64) s;(3.63 ± 1.41 )s; P ＜ 0.05) than their controls.2.Defensive-withdrawal test:when compare to the controls,PS offspring had greater latencies at P25,greater latencies and decreased number of exits from the chamber at P45,and greater latencies,decreased number of exits from the chamber and increased time in the chamber with restraint at P60 ( all P ＜ 0.05 ).On the contrary,the prenatal enriched offspring at 25 days of age had shorter latencies ( ( 10.43 ± 4.27 ) s; ( 22.16 ± 4.50) s; P ＜ 0.05 ) and increased number of exits from the chamber than their controis (6.34 ± 1.03 ;3.94 ± 1.08 ; P ＜ 0.05 ).Conclusion Environmental enrichment during pregnancy only can decrease fearfulness and enhance exploratory behavior of their infancy offspring.
