The expression and clinical significance of CXCR3/CXCL10 in human breast cancer

VernacularTitle:CXCR3/CXCL10在乳腺癌中的表达及临床意义
Author: Bofeng DUAN ; Wei ZHENG ; Meilai TANG ; Peizhi FAN ; Chaojie ZHANG ; Jing XIE ; Yang LI ; Shanshan LEI ; Xiaowen GU ; Jie HE
Publication Type:Journal Article
Keywords: Breast neoplasms/ME; Receptors,CXCR3/ME; Chemokine CXCL10/ME
From: Journal of Chinese Physician 2011;13(10):1305-1308
CountryChina
Language:Chinese
Abstract: Objective To investigate the expression and clinical significance of CXCR3/CXCL10in human cancer.Methods CXCR3 and CXCL10 were detected in 60 paraffinic tissues of patients with primary breast cancer,20 of mammary fibroma and 20 of mastopathy by immunohistochemistry S-P method and two stage method.Results The expression of CXCR3 (40/60,66.7％ ) and CXCL10 (45/60,75％)in breast cancer was higher than that in mastopathy [CXCR3(8/20,40％ )x2 =4.44,P =0.035 ;CXCL10( 10/20,50％ )x2 =4.36,P =0.037)].The expression of CXCR3 was related to status of axillary lymph node metastasis,clinical stage and the expression of HER-2 (x2 =4.15,P =0.042; x2 =7.74,P =0.021 ;x2 =4.27,P =0.039).The expression of CXCR3 had positive relationship to the number axillary lymph node metastasis( rs =0.375,P =0.003 ),clinical stage ( rs =0.451,P =0.000).Conclusions CXCR3 may be related to the progression and metastasis of breast cancer,and it may be used as a marker of breast cancer prognosis.