Study on the correlation between the polymorphism of STATS gene and asthma

VernacularTitle:STATS基因多态性与哮喘的相关性研究
Author: Juan DU ; Qingzhou FENG ; You ZUO ; Xuan LIU ; Huiling YE
Publication Type:Journal Article
Keywords: STATS transcription factor/GE; Polymorphism,genetic; Asthma/GE
From: Journal of Chinese Physician 2011;13(10):1316-1319
CountryChina
Language:Chinese
Abstract: Objective To investigate the correlation rs2272087 polymorphism of STATS gene and asthma.Methods The polymerase chain reaction PCR- SBT technique was used to determine rs2272087 polymorphism in asthma and control group.Results The genotype of AA,AG and GG of rs2272087 were 0.600,0.412 and 0.167 in asthma group,and 0.430,0.200,0.367 in control group,respectively.The frequency of allele A and G was 0.903 and 0.344 in asthma group,and 0.656,0.970 in control group,respectively.There was significant difference in two groups(x2 =9.40,P ＜0.01 ;x2 =11.58,P ＜0.01 ).Conclusions The rs2272087 polymorphism of STAT5 gene may be an important candidate gene for asthma.