Expression significance of Cyclin E in gastric cancer and lymphonode metastatic cancer
10.3760/cma.j.issn.1008-1372.2011.10.007
- VernacularTitle:Cyclin E在胃癌及淋巴结转移癌中的表达意义
- Author:
Ni XIE
;
Zhiwei ZHANG
;
Guohui TANG
;
Xiusheng. HE
- Publication Type:Journal Article
- Keywords:
Cyclin E/ME;
Stomach neoplasms/ME/SC;
Lymphatic metastasis
- From:
Journal of Chinese Physician
2011;13(10):1320-1322
- CountryChina
- Language:Chinese
-
Abstract:
Objective This study aimed to investigate the expression of Cyclin E protein in the progress of occurrence and development of gastric cancer and lymphonode metastatic cancer.Methods The expression of Cyclin E protein analyzed by immunohistochemistry in gastric tissue array included of normal gastric mucosa,cancer side tissues,atypical hyperplasia tissues,primary cancer tissues and lymphonode metastatic cancer tissues.Results The positive expression rate of Cyclin E protein was 14.3%,20.0%,34.7%,85.1% and 82.9% in normal gastric mucosa,atypical hyperplasia tissue,carcinoma side tissue,primary cancer and lymphonode metastatic cancer,respectively.Compared with normal gastric mucosa and carcinoma side tissues and atypical hyperplasia tissues,the Cyclin E protein in primary cancer and lymphonode metastatic carcinoma tissues was over-expression ( P < 0.01 ).Conclusions The Cyclin E protein was a possible molecular marker that can be used to diagnosis gastric cancer and lymphaden metastasis cancer.