The value of ischemia-modified albumin in early diagnosis of acute myocardial infarction
10.3760/cma.j.issn.1008-6315.2011.10.002
- VernacularTitle:缺血修饰白蛋白在急性心肌梗死早期诊断中的价值
- Author:
Mingzheng XU
;
Zhigang XI
;
Guozhong YU
;
Jifeng HE
;
Quanyou LIU
;
Jiting REN
- Publication Type:Journal Article
- Keywords:
Ischemia modified albumin;
Acute myocardial infarction
- From:
Clinical Medicine of China
2011;27(10):1012-1014
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the value of ischemia modified albumin (IMA) detection in preliminary diagnosis of acute myocardial infarction (AMI).Methods The levels and variations of IMA,cTnI and CK-MB in 103 patients with acute chest pain were measured continuously at 0,4,6,12,24 hours after admission respectively.Thirty healthy subjects were observed as normal controls.Results Twenty three patients were diagnosed as AMI in the end,the sensitivity and specificity rates right after admission were 89.3％ and91.3％ for IMA,48.4％ and 92.3％ for CK-MB,30.6％ and 93.7％ for cTnI respectively.The sensitivity values at the 6th hours after admission were 91.3％ for IMA,52.2％ for CTnI and 34.8％ for CK-MB respectively.The specificity was 100.0％ when the IMA was detected in combination with CK-MB or cTnI.The sensitivity of co-detection was significantly higher than that any single detection at sixth hours after admission (x2 =15.99,P ＜ 0.01 ).Conclusion Plasma IMA assessment is helpful for early diagnosis of AMI,and will significantly improve the sensitivity early diagnosis of AMI.The co-detection of IMA and CK-MB or cTnI obviously surpasses any single detection,and has extremely vital clinical significance.
