Study on the expression of PINCH and vascular endothelial growth factor C in cervical squamous cell carcinoma
10.3760/cma.j.issn.1008-6315.2011.10.004
- VernacularTitle:宫颈鳞癌组织中PINCH和血管内皮生长因子C蛋白表达的研究
- Author:
Yali MENG
;
Yan ZHENG
;
Liqin WANG
;
Xuehui LI
;
Zhenlong ZHU
;
Hongzhen ZHANG
- Publication Type:Journal Article
- Keywords:
PINCH protein;
Vascular endothelial growth factor C protein;
Cervical squamous cell carcinoma;
Clinical pathology;
Immunohistochemistry
- From:
Clinical Medicine of China
2011;27(10):1019-1022
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of PINCH and vascular endothelial growth factor C (VEGF-C) in cervical squamous cell carcinoma.Methods We detected the expression of PINCH and VEGF-C by immunohistochemistry SP in 58 cervical squamous cell carcinoma cases and 30 normal cervical epithelial tissue and analyzed their relationship to the clinical pathological features.Results The expression of PINCH and VEGF-C in 58 cervical squamous cell carcinoma(62.1％,36/58 ;67.2％,39/58 ) were higher than that in normal cervical epithelial tissue(0,0/30).The difference was significant( x2 =31.512,12.534,P ＜ 0.001 ).The expression of PINCH protein was not significantly associated with the age,tumor size and tumor differentiation grade ( P ＞ 0.05 ),but was associated with the lymph node metastasis and clinical stage ( x2 =9.090,8.236,P ＜ 0.001 ).The expression of VEGF-C had no significant correlationship with the age and tumor size( P ＞ 0.05 ) but had a correlationship with the lymph node metastasis,tumor differentiation grade and clinical stage( x2 =10.775,13.496,5.001,P ＜ 0.05 ).The expression of VEGF-C was correlated with the expression of PINCH protein( C =0.341,P ＜ 0.01 ).Conclusion It is possible that VEGF-C and PINCH take part in the development and progress of cervical squamous cell carcinoma and play an important role in the invasion and metastasis mechanism altogether.
