Effects of Alprostadil combined with Enalapril on high sensitivity C-reactive protein and cystatin in patients with early diabetic nephropathy
10.3760/cma.j.issn.1008-6315.2011.10.019
- VernacularTitle:前列地尔联合依那普利对早期糖尿病肾病患者血清超敏C-反应蛋白及胱抑素的研究
- Author:
Yanmin WANG
;
Zifen SUN
;
Xizhi XING
;
Pengxia LI
;
Jinpeng LIU
;
Haitao WANG
- Publication Type:Journal Article
- Keywords:
Diabetic nephropathy;
High sensitive C-reactive protein;
Cystatin;
Enalapril;
Alprostadil
- From:
Clinical Medicine of China
2011;27(10):1062-1065
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effects of Alprostadil combined with Enalapril on high sensitivity C-reactive protein and Cystatin in patients with early diabetic nephropathy.Methods One hundred and fifteen cases of outpatients were randomized into 3 groups.Thirty-seven cases were assigned to Alprostadil group and treated with Alprostadil 10 μg + NS 100 ml,iv,qid;Thirty-eight cases were assigned to the Analapril group and treated with Enalapril 5 mg bid;Forty cases were assigned to the combined treatment group and treated with Alprostadil 10 μg + NS 100 ml,iv qid and Enalapril 5mg bid.All patients were observed for twelve weeks.Changes before and after treatment in the blood pressure,plasma glucose,glycolated hemoglobin (HbA1 c),24 hours urinary albumin (24 hUAE),high-sensitive C-reactive protein(hs-CRP) and Cystain C( Cys C) were observed and compared between the three groups.Results After treatment,hs-CRP,CysC and 24 h UAE were significantly improved in the three groups compared with baseline levels( P ＜ 0.05).In the combined treatment group,hs-CRP,CysC and 24 h UAER had a more significant improvement than the other two groups (P ＜0,05 ).Conclusion Alprostadil combined with Enalapril is a clinically effective strategy in the treatment of early diabetic nephropathv and can reduce the levels of CysC and hs-CRP.
