The safety of hydroxychloroquine in pregnant patients with systemic lupus erythematosus

VernacularTitle:羟氯喹治疗系统性红斑狼疮合并妊娠24例临床研究
Author: Lu ZHANG ; Li MA ; Bing LIN ; Donghai WU ; Guochun WANG
Publication Type:Journal Article
Keywords: Lupus erythematosus,systemic; Pregnancy; Hydroxychloroquine
From: Chinese Journal of Internal Medicine 2011;50(11):918-921
CountryChina
Language:Chinese
Abstract: ObjectiveTo evaluate the efficacy and safety of hydroxychloroquine(HCQ) in pregnant patients with systemic lupus erythematosus (SLE).Methods Twenty-four pregnant patients with SLE treated with HCQ during pregnancy from May,2006 to February,2011 were studied retrospectively.All babies were followed up during early infancy for growth development.ResultsOf them,22 patients were treated with HCQ throughout the whole pregnancy with no lupus flare occurred in 21 patients (95.4％),while temporary discontinuation of HCQ precipitated a flare of disease in two patients.Three patients ( 12.5％ ) had premature delivery,and pregnancy induced hypertension happened in 3 patients (12.5％ ).No congenital abnormalities occurred and mean follow-up of 26 months ( range 1 - 47 months) revealed no abnormalities in these children.Conclusion Our findings reinforce the safety of HCQ therapy during pregancy and HCQ should probably be maintained throughout the pregancy in patients with SLE.