Significance and expression of p-STAT3 and survivin in primary gallbladder carcinoma

VernacularTitle:胆囊癌组织中p-STAT3、survivin的表达及意义
Author: Weifu YANG ; Zhenfeng WU ; Zhaofang. ZHU
Publication Type:Journal Article
Keywords: Gallbladder neoplasms/ME; STAT3 transcription factor/ME; Microtubule-associated proteins/ME
From: Journal of Chinese Physician 2011;13(10):1327-1329
CountryChina
Language:Chinese
Abstract: Objective To detect the expression of p-STAT3 and survivin in primary gallbladder carcinoma (PGC) and explore its significance for the genesis and development of PGC.Methods The expression of p-STAT3 and survivin were determined with immunohistochemistry in samples from 45 PGC tissues and 20 chronic cholecystitis.The relationship between the expression of these proteins and various clinicopathological factors was evaluated.Results The expression rate of p-STAT3 and survivin in 45 PGC tissues was 55.6％ ( 25/45 ) and 64.4％ ( 25/45 ),respectively,which was significantly higher than those in 20chronic cholecystitis tissues 5.0％ ( 1/20),10％ ( 2/20 ) ( P ＜ 0.01 ).pSTAT3 expression was correlated with survivin ( r =0.830,P ＜0.01 ).p-STAT3 and survivin protein expression were significantly associated with histopathological grading,lymph node metastatis,nevin staging and 3-year survival rate.Conclusions p-STAT3 and survivin might play a vital role in the development of PGC.The expression of p-STAT3 or survivin was an independent prognostic factor in PGC.