The effects of rosmartnic acid on the urine toxins,urinary protein ,serum MDA and SOD in the rats with the 5/6 nephrectomy
10.3760/cma.j.issn.1008-6315.2011.10.023
- VernacularTitle:迷迭香酸对5/6肾切除大鼠尿毒素、尿蛋白及血清丙二醛和超氧化物歧化酶的影响
- Author:
Weiyuan LIN
;
Ronggui HUANG
;
Xingzhong ZHENG
- Publication Type:Journal Article
- Keywords:
Rosmarinic acid;
Nephretomy;
Urine protein;
Creatinine clearance rate;
MDA;
SOD
- From:
Clinical Medicine of China
2011;27(10):1075-1077
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of rosmarinic acid on the kidney function,urinary protein,serum MDA and SOD in rats with the 5/6 nephrectomy.Methods We established the rat model with chronic renal dysfunction and randomized them into normal control group,model control group and rosmarinic acid treatment group.There were 6 rats in each group.The blood creatinine level was recorded 2 weeks after operation.We detected the effects of rosmarinic acid on urinary protein,urine creatinine,blood creatinine,serum MDA and SOD in rats with the 5/6 nephretomy which was established by Ponseau S method.The treatment group received rosmarinic acid as an intervention.Results ( 1 ) Compared with control group,the creatinine and The creatinine clearance rate ( Ccr ) of rosmarinic acid treatment group increased ( F =38.912,P ＜ 0.01 ;F =19.968,P ＜ 0.05 ) after treatment,; (2) Rosmarinic acid improved the 24 h urine protein in rats with renal dysfunction significantly(F =16.288 P ＜0.01); (3) Rosmarinic acid had no effect on serum MDA and SOD in rats.Conclusion Rosmarinic acid can decrease urine protein and blood creatinine,increase the Ccr and alleviate kidney failure,but has no effects on MDA and SOD in rat model.
