The value of magnetic resonance imaging in treatment efficacy evaluation of polymyositis and dermatomyositis
10.3760/cma.j.issn.1007-7480.2011.10.007
- VernacularTitle:磁共振成像在多发性肌炎和皮肌炎治疗评价中的初探
- Author:
Yun ZHU
;
Xianfeng YANG
;
Xiaolei MA
;
Bingzhu HUA
;
Xia LI
;
Bin ZHU
;
Lingyun SUN
- Publication Type:Journal Article
- Keywords:
Polymyositis;
Dermatomyositis;
Magnetic resonance imaging
- From:
Chinese Journal of Rheumatology
2011;15(10):687-689
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the role of magnetic resonance imaging (MRI) in treatment efficacy evaluation of polymyositis and dermatomyositis.MethodsFifteen patients with polymyositis and dermatomyositis underwent MRI of thigh were included.Scores of MRI signal intensity of the diseased muscle of every patient were compared before and after treatment and the correlation between serum creatinkinase (CK) level and muscle strength grade were also compared.Correlations between muscle strength grade and MRI score,as well as muscle strength grade and creatinkinase level were analyzed.Comparisons between groups were tested by t test,and the relationship between muscle strength and clinical data was analyzed by Pearson's correlation analysis.ResultsThe signal score of MRI was counted before and after therapy(2.37±0.62,1.30±0.28,respectively,P＜0.05),and CK level[(3841±3175),(549±338) U/L,respectively,P＜0.05] and muscle strength (15.1 ±2.4,18.1 ±0.9,respectively,P＜0.05) were assessed at the same time.Muscle strength grade was associated with signal score of MRI and serum CK level,there was a strong correlation between muscle strength grade and signal score of MRI(r=-0.890,P＜0.05 ).ConclusionMRI may be a useful tool for clinical efficacy evaluation in patients with polymyositis and dermatomyositis.
