Cholangiocarcinoma of the hepatic hilum: surgical management and prognosis

VernacularTitle:肝门部胆管癌的外科治疗和预后因素分析
Author: Lishan XU ; Wensheng LIU
Publication Type:Journal Article
Keywords: Hilar cholangiocarcinoma; Surgical procedure; Prognosis
From: Chinese Journal of Hepatobiliary Surgery 2011;17(10):829-832
CountryChina
Language:Chinese
Abstract: Objective To analyze the surgical management and prognosis of hilar cholangiocarcinoma(HCC).MethodClinical data of 72 patients with HCC were retrospectively analyzed.Results There was a significant difference in the 3- and 5- year survival rates and median survivals among the groups treated with different surgical methods(x2 =28.1,P＜ 0.01 ).Univariate analyses conducted for the 16 factors which might affect prognosis showed the surgical method,lymphatic metastasis,positive margin,as well as the type of pathology and staging were of statistically significant prognostic value (P＜0.05).On a multivariate analysis using the Cox proportional hazards model,surgical management,lymphatic metastasis and the type of pathology and staging were independent prognostic factors (regression coefficient 1.4157,1.1072,1.6435).ConclusionRadical excision is an important prognostic factor for HCCa and extended resection improved the long-term survival rates of radical surgery.