Association of hyaluronic acid and soluble intercellular adhesion molecule-1 with the activity of Graves' ophthalmopathy

VernacularTitle:血清可溶性细胞间黏附分子1、透明质酸水平与Graves眼病疾病活动性之间的关系
Author: Xiaozhen YE ; Jian WANG ; Lanping HU ; Yangtian WANG ; Jie LI ; Yanyan WANG
Publication Type:Journal Article
Keywords: Graves' ophthalmopathy; Soluble intercellular adhesion molecule-1; Hyaluronic acid; Association
From: Chinese Journal of Endocrinology and Metabolism 2011;27(10):830-832
CountryChina
Language:Chinese
Abstract: To investigate weather serum soluble intercellular adhesion molecule-1 (sICAM-1) and hyaluronic acid(HA) levels can be used in assessing the disease activity of Graves' ophthalmopathy (GO).Serum levels of sICAM-1 and HA were determined in 48 cases with GO and 30 cases with Graves' disease without GO (CON).Compared with the CON group,the levels of sICAM-1 and HA in GO cases were raised significantly( P＜0.05 ).sICAM-1 and HA levels in the subgroup of patients with active GO were markedly elevated when compared to those with stable GO(P＜0.05 ).Pearson regression analysis showed that elevated levels of slCAM-1 and HA were positively correlated with the Clinical Activity Score ( CAS ) of GO ( r =0.53,P ＜ 0.01 ; r =0.46,P ＜ 0.01 ) ; A significant correlation between sICAM-1 and HA( r=0.31,P＜0.05 ) was noted.The raised serum levels of sICAM-1and HA may serve as two activity markers of GO.