Association of hyaluronic acid and soluble intercellular adhesion molecule-1 with the activity of Graves' ophthalmopathy
10.3760/cma.j.issn.1000-6699.2011.10.012
- VernacularTitle:血清可溶性细胞间黏附分子1、透明质酸水平与Graves眼病疾病活动性之间的关系
- Author:
Xiaozhen YE
;
Jian WANG
;
Lanping HU
;
Yangtian WANG
;
Jie LI
;
Yanyan WANG
- Publication Type:Journal Article
- Keywords:
Graves' ophthalmopathy;
Soluble intercellular adhesion molecule-1;
Hyaluronic acid;
Association
- From:
Chinese Journal of Endocrinology and Metabolism
2011;27(10):830-832
- CountryChina
- Language:Chinese
-
Abstract:
To investigate weather serum soluble intercellular adhesion molecule-1 (sICAM-1) and hyaluronic acid(HA) levels can be used in assessing the disease activity of Graves' ophthalmopathy (GO).Serum levels of sICAM-1 and HA were determined in 48 cases with GO and 30 cases with Graves' disease without GO (CON).Compared with the CON group,the levels of sICAM-1 and HA in GO cases were raised significantly( P<0.05 ).sICAM-1 and HA levels in the subgroup of patients with active GO were markedly elevated when compared to those with stable GO(P<0.05 ).Pearson regression analysis showed that elevated levels of slCAM-1 and HA were positively correlated with the Clinical Activity Score ( CAS ) of GO ( r =0.53,P < 0.01 ; r =0.46,P < 0.01 ) ; A significant correlation between sICAM-1 and HA( r=0.31,P<0.05 ) was noted.The raised serum levels of sICAM-1and HA may serve as two activity markers of GO.