Relationship of positive rate of β1-adrenergic and AT1 receptor autoantibodies with serum cystatin C concentration in the patients with diabetic nephropathy
10.3760/cma.j.issn.1000-6699.2011.10.013
- VernacularTitle:糖尿病肾病患者血清AT1受体和β1受体自身抗体与血清半胱氨酸蛋白酶抑素C的关系
- Author:
Linshuang ZHAO
;
Guangda XIANG
;
Jinhui PU
;
Yuhua LIAO
;
Min WANG
;
Jie HOU
;
Ling YUE
;
Huiling SUN
;
Xueying TAN
- Publication Type:Journal Article
- Keywords:
Diabetic nephropathy;
Receptors,angiotenisn Ⅱ type 1;
Receptors,adrenergic β1;
Autoantibodies;
Cystatin C
- From:
Chinese Journal of Endocrinology and Metabolism
2011;27(10):833-835
- CountryChina
- Language:Chinese
-
Abstract:
To observe the relationship between positive rate of β1-adrenergic and AT1 receptors autoantibodies with serum concentration of cystatin C in 371 patients with diabetic nephropathy patients,107 patients with type 2 diabetes,and 47 subjects as healthy control.In patients with diabetic nephropathy,the positive rates of the β1 and AT1 receptors autoantibodies were significantly higher than those in patients with type 2 diabetes and normal controls.The titers of β1 and AT1 receptors autoantibodies in diabetic nephropathy patients with abnormal cystatin C were significantly higher than those with normal cystatin C concentration.These findings suggested that β1 and AT1 receptors autoantibodie may play important roles in the pathogenesis of diabetic nephropathy.
