Association of brain-derived neurotrophic factor gene polymorphisms with the risk of pediatric epilepsy
10.3760/cma.j.issn.1674-6554.2011.10.015
- VernacularTitle:脑源性神经营养因子基因多态性与小儿癫痫的关联研究
- Author:
Yongxiang CHEN
;
Jing WANG
;
Fengjing LI
;
Yan QIN
;
Jie HUANG
- Publication Type:Journal Article
- Keywords:
Pediatric epilepsy;
Brain-derived neurotrophic factor gene;
Polymorphism;
Haplotype
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2011;20(10):907-909
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between brain-derived neurotrophic factor (BDNF)gene polymorphisms and the susceptibility to pediatric epilepsy.Methods BDNF polymorphisms in 128 patients with pediatric epilepsy and 132 healthy controls were analyzed with polymerase chain reaction restriction and fragment length polymorphism (PCR-RFLP).Results There were significant differences between pediatric epilepsy and controls on genotype frequency of BDNF-270C/T (X2 =7.08,P =0.03 ).The CC genotype was positively associated with pediatric epilepsy (OR =3.91,95％CI =1.26 ～ 12.14).No differences in genotype or allele frequencies of the other polymorphisms were found between patients and controls.The frequencies of haplotypes did not show significant differences between patients and controls.Conclusion These findings support the hypothesis that BDNF-270C/T polymorphism may contribute to the risk of developing pediatric epilepsy.
