Is Thyroid Hormone a Risk Factor of Coronary Atherosclerosis in Korean Patients?.
- Author:
Kyung Ho YUN
1
;
Myung Ho JEONG
;
Dong Goo KANG
;
Kye Hun KIM
;
Sang Yup LIM
;
Yeon Sang LEE
;
Sang Hyun LEE
;
Seo Na HONG
;
Young Joon HONG
;
Ju Han KIM
;
Young Keun AHN
;
Jeong Gwan CHO
;
Jong Chun PARK
;
Nam Ho KIM
;
Seok Kyu OH
;
Jin Won JEONG
;
Jung Chaee KANG
Author Information
- Publication Type:Original Article
- Keywords: Thyroid gland; Coronary disease; Arteriosclerosis
- MeSH: Angina, Stable; Angina, Unstable; Arteriosclerosis; Atherosclerosis; C-Reactive Protein; Constriction, Pathologic; Coronary Angiography; Coronary Artery Disease*; Coronary Disease; Diagnosis; Fibrinogen; Homocysteine; Humans; Hypothyroidism; Incidence; Male; Monocytes; Myocardial Infarction; Reference Values; Risk Factors*; Thyroid Gland*; Thyroid Hormones; Thyroxine
- From:Korean Circulation Journal 2005;35(1):43-48
- CountryRepublic of Korea
- Language:Korean
- Abstract: BACKGROUND AND OBJECTIVES: Overt and subclinical hypothyroidism is known to be associated with developing atherosclerosis and adverse changes in blood lipid. There has been no data regarding the effects of a normal range of thyroid hormone on the presence of coronary atherosclerosis. SUBJECTS AND METHODS: We studied 1 25 consecutive patients (age: 60.0 +/-11.1 years, male: female=84:41) who underwent diagnostic coronary angiography. The clinical diagnoses on admission were stable angina (32.0%), unstable angina (53.6%), and acute myocardial infarction (14.4%). The thyroid hormones [thyroid stimulating hormone (TSH), free thyroxine and free 3 -iodothyronine], serum lipid levels, high sensitivity C-reactive protein (hsCRP) level, homocysteine and fibrinogen levels were measured. The coronary angiographic results were compared with laboratory findings. RESULTS: The angiographic diagnoses of coronary artery disease were no significant stenosis in 4 1 patients (32.8%), single vessel disease in 47 patients (37.6%) and multivessel disease in 37 patients (29.6%). The serum TSH levels showed a trend toward higher levels in the patients with multivessel disease compared to the patients with no significant stenosis (1.22+/-0.96 uIU/mL vs. 0.73+/-0.53 uIU/mL, respectively, p=0.053). According to the levels of TSH (<1.0 uIU/mL and > or =1.0 IU/mL), the incidence of multivessel disease was significantly higher in the patients with high serum TSH levels (23.1 % vs. 40.0%, respectively, p=0.038). A significant correlation was observed between the levels of TSH and the monocyte count (r=0.251, p=0.005), hsCRP level (r=0.208, p=0.023) and homocysteine level (r=0.279, p=0.002). CONCLUSION: The high level of serum TSH is associated with multivessel disease, abnormal inflammatory markers and high homocysteine levels.
