Role of circadian rhythm change in the pathogenesis of obesity and diabetes
10.3760/cma.j.issn.1000-6699.2011.10.002
- VernacularTitle:昼夜节律变化在肥胖和糖尿病发病中的作用
- Author:
Libin ZHOU
;
Mingdao CHEN
- Publication Type:Journal Article
- Keywords:
Circadian rhythms;
Obesity;
Diabetes mellitus;
Shift work
- From:
Chinese Journal of Endocrinology and Metabolism
2011;27(10):793-795
- CountryChina
- Language:Chinese
-
Abstract:
Increasing clinical evidence shows that modern lifestyle interrupting circadian rhythm contributes to the prevalence of obesity and diabetes.Recent genetic animal models further support the interaction of circadian rhythms and metabolic state.Circadian clock is not limited to be in central nervous system,and is also present in nearly all cells of the body,which constitute hierarchically circadian systems.The molecular circadian clock is evolved to allow organisms to anticipate and prepared for predictable,daily changes in the environment and regulates cellular and tissue function by driving patterns of gene expression and enzymatic activity.At present,basic science in this field has progressed at an extraordinary pace and is expected to continue unraveling the mechanisms linking circadian clocks to metabolism,which is important for understanding the pathophysiology of metabolic diseases such as obesity and diabetes,and provides a conceptual basis for the prevention and therapeutics of these diseases.
