Analysis of risk factors of metabolic syndrome in obese subjects: a follow-up study
10.3760/cma.j.issn.1000-6699.2011.10.009
- VernacularTitle:随访肥胖人群中代谢综合征发生的相关因素分析
- Author:
Lüyun ZHU
;
Liye HU
;
Xiaoling LI
;
Guangyu WANG
;
Shaoling YANG
- Publication Type:Journal Article
- Keywords:
Metabolic syndrome;
Obesity;
Insulin resistance;
Endothelial function;
Follow-up study
- From:
Chinese Journal of Endocrinology and Metabolism
2011;27(10):821-824
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the risk factors of metabolic syndrome ( MS ) in obese subjects.Methods A seven-year follow-up study was conducted in 413 simple obese subjects and 196 subjects with normal body weight who were recruited from community residents during physical examination in 2000.There was a 7 years follow-up.Anthropometrics,blood pressure,lipid profile,fasting blood glucose,and 2 h blood glucose after glucose loading were measured.Endothelium-dependent dilatation (EDD) test was also performed.Results Among 553 of 609 subjects who were followed up in 2007,there were 381 simple obese subjects ( simple obese group) and 172 normal weight subjects( normal weight group).Seven-year cumulative incidence of MS was 35.17% in simple obese group and 8.14% in normal weight group.In simple obese group,subjects with MS showed greater or higher levels of waist circumference( WC ),waist-hip ratio ( WHR ),triglyceride ( TG ),fasting plasma glucose ( FPG ),fasting insulin (FINS),and homeostasis model assessment for insulin resistance index (HOMA-IR) (all P<0.05 ),and also decreased EDD( P<0.05 ) as compared with those without MS.WC,WHR,and FINS were higher( all P<0.05 ) and EDD was lower( P<0.05 ) in subjects with MS of normal weight group than those without MS.Logistic analysis showed that the male gender,WC,WHR,FPG,HOMA-IR,and EDD were major risk factors of MS.Conclusion Central obesity,insulin resistance,and endothelial dysfunction are important independent risk factors for development of MS.