Association of polymorphisms of eIF4E and MMP-9 genes with psoriasis vulgaris in Han population of Shandong province
10.3760/cma.j.issn.0412-4030.2011.10.004
- VernacularTitle:山东汉族寻常性银屑病患者eIF4E、MMP-9基因多态性研究
- Author:
Daxing CAI
;
Qing SUN
;
Weiyuan MA
;
Hua ZHONG
;
Chunyang LI
- Publication Type:Journal Article
- Keywords:
Psoriasis;
Matrix metalloproteinase 9;
Gene;
Han nationality;
Shandong
- From:
Chinese Journal of Dermatology
2011;44(10):697-699
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association of eIF4E and MMP-9 gene polymorphisms with psoriasis vulgaris in Han population of Shandong province.Methods A population based case-control association study was carried out in 188 patients with psoriasis vulgaris and 280 healthy human controls of Han nationality from Shandong province.Taqman SNP genotyping assay was performed to assess three SNPs,including rs4810482 and rs3918254 in MMP-9 gene and rs11723037 in eIF4E gene.Pairwise linkage disequilibrium was evaluated by using Haploview 4.2 software,and the frequencies of alleles and genotypes were analyzed by using Plink 1.07 software.Results The frequency of rs4810482 T allele was significantly lower in patients with psoriasis vulgaris than in the normal human controls(OR =1.49,95％ CI:1.12-1.99,P ＜ 0.01),and the significant difference still remained under recessive and dominant model.Bioinformatic analysis revealed that the rs4810482 altered the binding site of transcription factor,while no association was observed between psoriasis and either of the other two SNPs.Conclusions The SNP rs4810482 located at the upstream regulatory region of MMP-9 gene is significantly associated with psoriasis,hence,MMP-9 gene may be a susceptibility gene for psoriasis in Han population of Shandong province.
