Expression of granulocyte macrophage-colony stimulating factor in patients with psoriasis

VernacularTitle:银屑病患者粒-单核巨噬细胞集落刺激因子表达的研究
Author: Xin XIE ; Li CHAI ; Yicheng ZHOU ; Na AN ; Jing TIAN
Publication Type:Journal Article
From: Chinese Journal of Dermatology 2011;44(10):731-732
CountryChina
Language:Chinese
Abstract: Objective To investigate the expression of granulocyte macrophage-colony stimulating factor(GM-CSF)in skin lesions and sera of patients with pustular psoriasis and psoriasis vulgaris.Methods Tissue specimens were obtained from the lesions of 15 patients with pustular psoriasis,15 patients with psoriasis vulgaris and 15 normal human controls.Immunohistochemistry and dual antibody sandwich enzyme-linked immunosorbent assay(ELISA)were carried out to detect the levels of GM-CSF in the tissue and serum specimens from the patients and normal human controls,respectively.Results Significantly higher levels of GM-CSF were observed in the tissue and serum specimens from patients with pustular psoriasis and psoriasis vulgaris compared with the normal controls(all P ＜ 0.01),as well as in those from the patients with pustular psoriasis compared with the patients with psoriasis vulgaris(both P ＜ 0.01).Conclusion GM-CSF may be involved in the pathogenesis of psoriasis.