Effects of acitretin on the level of interleukin-8(IL-8)in the peripheral blood of patients with pustular psoriasis

VernacularTitle:阿维A对脓疱性银屑病患者外周血IL-8水平的影响
Author: Jing TIAN ; Yicheng ZHOU ; Shuyun ZHENG ; Limei SUN ; Xin XIE
Publication Type:Journal Article
From: Chinese Journal of Dermatology 2011;44(10):732-734
CountryChina
Language:Chinese
Abstract: Objective To investigate the changes of IL-8 in peripheral blood of patients with pustular psoriasis after acitretin treatment.Methods Dual antibody sandwich enzyme-linked immunosorbent assay (ELISA)was performed to measure the IL-8 levels in the peripheral blood of 30 patients with pustular psoriasis and 30 patients with psoriasis vulgaris before and after treatment,and in 30 normal human controls.The relationship between the IL-8 level and disease severity was assessed for patients with pustular psoriasis.Results After acitretin treatment,the condition was improved greatly in patients with pustular psoriasis,together with a significant decrease in the level of IL-8 in the peripheral blood(57.07 ± 12.02 pg/ml vs.96.84 ± 14.68 pg/ml,P ＜ 0.05).Conclusion IL-8 may be involved in the therapeutic mechanism of acitretin in pustular psoriasis.