The relationships of collateral formation in patients with serious coronary artery disease and endothelial progenitor cells
10.3760/cma.j.issn.1008-1372.2011.09.007
- VernacularTitle:冠状动脉严重狭窄的稳定型心绞痛患者侧支循环与内皮祖细胞的关系研究
- Author:
Xuewen QI
;
Haifeng LIU
;
Longle MA
;
Mengzan WANG
- Publication Type:Journal Article
- Keywords:
Coronary stenosis/CO;
Angina pectoris/ME/PA;
Collateral circulation;
Endothelial cells
- From:
Journal of Chinese Physician
2011;13(9):1177-1180
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of endothelial progenitor cells (EPCs) on the development of collateral formation in stable angina patients with serious coronary artery disease.Methods The subjects were patients ( n =92) who underwent coronary angiography (CAG) and had chronic total occlusion (CTO) in one major coronary artery.They were divided into two groups,patients without collaterals (coil-,n =50) and patients with collaterals (coll +,n =42).EPCs were isolated from peripheral blood samples and cultured.The numbers of colony-forming units (CFUs) and the vasculargenesis capacity in vitro was assayed respectively.The plasma level of SDF-1α was determined by enzyme linked immunosorbent assay.Results The number of colony-forming units ( CFUs ) [ ( 22.10 ± 4.69 ) CFUs/106 EPCs vs ( 16.90 ± 3.66) CFUs/106 EPCs ],vasculogenesis capacity in vitro (25.3 ± 3.2 vs 17.4 ± 2.6) and plasma level of SDF-1 α[ (243.7 ± 19.2 ) ng/ml vs ( 203.1 ± 17.8) ng/ml,P ＜ 0.01 ] in coll + group were higher than that of coll group.It had a positive correlation between the level of collateral circulation and the numbers of CFUs,vascular genesis activity of circulating EPCs and plasma level of SDF-1αt( r =0.74,0.69,0.82,0.81,0.64,P ＜ 0.01 ).Conclusions The number of CFUs and vasculargenesis activity of EPC in coll + group with serious coronary artery disease is significantly higher than that in coll- group.These changes may be related to the increase of plasma SDF-1 α.The method improving the numbers and function of EPCs,increasing the activity of SDF-1 α may benefit the patients with coronary artery disease.
