Dose-effect relationship of chromosome aberrations induced by different LET rays at low doses
10.3760/cma.j.issn.0254-5098.2011.05.006
- VernacularTitle:不同传能线密度射线0～1Gy照射诱发染色体畸变的量-效关系研究
- Author:
Fagui ZENG
;
Chuangao WANG
;
Jie DU
;
Zhidong WANG
;
Xiaofeng MU
;
Kunpeng LI
;
Xueqing ZHANG
;
Ying CHEN
- Publication Type:Journal Article
- Keywords:
Ionizing radiation;
Linear energy transfer;
Low doses;
Chromosome aberrations;
Dose-effect curve
- From:
Chinese Journal of Radiological Medicine and Protection
2011;31(5):531-535
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish the dose-effect curves of chromosome aberrations in human peripheral blood lymphocytes induced by different LET rays,including 60Co γ-rays,252Cf neutrons,14MeV neutrons and 12C heavy ions at low doses,respectively,in order to assess radiation-induced damages after occupational and accidental exposure.Methods Heparinized whole blood samples were irradiated with the various radiation devices and doses ranged from 0 to 1 Gy with the interval of 0.25 Gy.Conventional chromosome culture method was applied with adding colchicines at the beginning and chromosome specimens were prepared after 48 h incubation.The Metafer scanning system was used for automatical finder of chromosome metaphases.The mathematic models were fitted according to aberration data obtained.Results At the dose range of 0 - 1 Gy,the math models of dic + r were linear for 60 Co γrays and linear-quadratics for 252 Cf neutrons,14 MeV neutrons and 12 C heavy ions.The models of ace were linear-quadratic for 60Co γ-rays and 12C heavy ion beams,and linear for 252Cf and 14 MeV neutrons.The models of total aberrations were linear-quadratic for all types of radiation.Conclusions High LET rays have higher biological effects in inducing chromosome aberrations yields compared with low LET rays.Moreover,the severity of damage is 252Cf ＞ 14 MeV neutrons ＞ 12C heavy ions ＞ 60Co γ-rays in turn.Therefore,in the range of low doses,the dic + r may be a better target of radiation damage for high LET radiation.
