A priliminary study on the prevention and early treatment of Nimodipine for type 2 diabetes mellitus with mild cognitive impairment

VernacularTitle:尼莫地平对伴轻度认知功能损害2型糖尿病患者早期防治初探
Author: Ruya GUO ; Aiming GU ; Zhengqi GAN ; Lishu FANG
Publication Type:Journal Article
Keywords: Diabetes mellitus,type 2; Mild cognitive impairment; Prevention; Treatment; Nimodipine
From: Chinese Journal of Endocrinology and Metabolism 2011;27(10):836-838
CountryChina
Language:Chinese
Abstract: Ninty-eight patients of type 2 diabetes mellitus with mild cognitive impairment were collected according to the Montreal Cognitive Assessment( MoCA )and mismatch negativity( MMN ).Forty-eight patients were assigned to conventional treatment with nimodipine (20 mg/d).The MoCA and MMN were evaluated and compared with the remaining 50 patients who served as a control group.There was no significant difference between two patient groups in MoCA( P＞0.05 ) ;the latency and amplitude of MMN were significantly improved in the treated group( P＜0.05 ) ; the amplitude of MMN was reduced in control group ( P＜0.05 ),but the latency of MMN showed no significant change( P＞0.05 ).