Influence of mirtazapine on polysomnograpy and treatment effect of depression dysphylaxia patients
10.3760/cma.j.issn.1674-6554.2011.09.017
- VernacularTitle:米氮平对早醒抑郁症患者睡眠脑电图及临床疗效的影响
- Author:
Huimin HAN
;
Guangcheng CUI
;
Ameng ZHAO
;
Dongruo HE
;
Zhilei HE
;
Na WANG
;
Wei HAN
- Publication Type:Journal Article
- Keywords:
Mirtazapine;
Depression;
Dysphylaxia;
Polysomnograpy
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2011;20(9):818-820
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate influence of mirtazapine on polysomnograpy (PSG) of depression dysphylaxia patient and treatment effect.Methods 22 dysphylaxia patients and 22 healthy contrast persons were detected by PSG.The group of dysphylaxia patients were re-detected PSG 6 weeks later after treatment by Mirtazapine.In order to evaluate the patient' symptoms of depression and early awakening,the scale of HAMD was utilized at the time before and after 2 weeks,6 weeks treatment by mirtazapine.To compare changes of PSG index,HAMD scores and dysphylaxia scores before and after treatment.Results Compared with healthy controls,there existed much deviation with dysphylaxia patients on PSG index.6 weeks after mirtazapine treatment,the PSG showed the sleeping latency had shortened to ( 16.9 ± 6.6) min,sleep efficiency had improved ( 85.4 ± 6.7 ) ％,awake time had shortened (27.7 ± 10.4)min,sleep maintenance rate had risen (87.9 ±5.3)％,decrease (9.7±4.1 )％ of the S1 sleeping stage percentage,S2 had increased ( 148.0 ±30.7)％,REM density had decreased (56.1 ±3.8)％.the difference was significant (P＜0.05).The scores of HAMD and early awakening after treatment were significantly lower than before treatment,the difference was significant (P＜0.01 ).Correlation analysis showed there was no significant correlation between the HAMD,dysphylaxia reduced rate and changes of PSG all indicators(P ＞ 0.05 ).Conclusion It may be one of the biological markers for dysphylaxi in shortened of REM sleep latency,prolonged of REM sleep time and increased of REM activity and density.There is no correlation between post-treatment changes of PSG.
