Efficacy of different doses of urapidil in preventing pituitrin-induced cardiovascular responses in patients undergoing laparoscopic myomectomy
10.3760/cma.j.issn.0254-1416.2011.07.004
- VernacularTitle:不同剂量乌拉地尔预防垂体后叶素诱发腹腔镜子宫肌瘤剥除术患者心血管反应的效果
- Author:
Tieying SONG
;
Pengyu MA
;
Guohua GAO
;
Yanchao YANG
;
Chunping WANG
;
Jian YA
;
Bo JIANG
;
Kun MA
;
Yunshui PENG
- Publication Type:Journal Article
- Keywords:
Piperazines;
Pituitary hormones,posterior;
Laparoscopy;
Leiomyoma;
Gynecologic surgical procedures;
Hemodynamics
- From:
Chinese Journal of Anesthesiology
2011;31(7):792-794
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo evaluate the efficacy of different dones of urapidil in preventing pituitrin-induced cardiovascular responses in patients undergoing laparoscopic myomectomy.MethodsSixty ASA Ⅰ or Ⅱ patients,aged 27-41 yr,weighing 55-65 kg,scheduled for elective laparoscopic myomectomy under general anesthesia,were randonly divided into 4 groups (n =15 each):control group (group C) and urapidil 0.3,0.5 and 0.8 mg/kg groups (groups U1-3).Urapidil 0.3,0.5 and 0.8 mg/kg were injected intravenously in U1-3 groups respectively,while normal saline 5 ml was given in group C.The mixture of pituitrin 6 U and normal saline 20 ml was injected into the site of hysteromyoma 5 min later.The operation was then started.BIS value was maintained at 45-55.The occurrence of cardiovascular responses was recorded.ResultsThe incidences of cardiovascular responses were 100％,67％,40％ and 20％ in groups C and U1-3 respectively.The incidence of cardiovascular responses was significantly lower in groups U1-3 than in group C,and in groups U2.3 than in group U1 ( P ＜ 0.01 ).There was no significant difference in the incidence of cordiovascular responses between U2 and U3 groups (P ＞ 0.05).ConclusionUrapidil can prevent pituitrin-induced cardiovascular responses in patients undergoing laparoscopic myomectomy and the optimal dose is 0.5 mg/kg.
