Effect of dopamine D4 receptor agonist ABT-724 on behaviors in rat model of attention-deficit hyperactivity disorder
10.3760/cma.j.issn.1674-6554.2011.09.011
- VernacularTitle:多巴胺D4受体激动剂ABT-724对注意缺陷多动障碍模型大鼠行为的影响
- Author:
Lin YU
;
Aihua CAO
;
Xiaona LV
;
Gefei LEI
- Publication Type:Journal Article
- Keywords:
ABT-724;
SHR;
Spontaneous locomotor activity;
Cognitive ability;
Non-selective attention
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2011;20(9):800-802
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of a highly selective dopamine D4 receptor (ABT-724)on behaviors in Spontaneously hypertensive rats (SHR),a rat model of attention-deficit hyperactivity disorder (ADHD).Methods After intervention of methylphenidate(5mg/kg) and three different doses of ABT-724(0.04mg/kg,0.16mg/kg,0.64mg/kg),behaviors of SHR were verified by open-field test,Morris water maze and Làt maze.Results Number of square crossing after intervention of methylphenidate and ABT-724 in SHR( 70.67 ± 8.59,76.50 ± 10.75,79.17 ± 10.44,65.67 ± 20.62) was less than the saline control group( 130.33 ± 1 1.40) (P＜0.05).During Morris water maze,SHRs(52.50 ± 4.04,52.17 ± 2.99,61 ± 8.15,53.83 ± 9.87 ) after intervention of both had a better spatial memory ability than control group(38.83 ±7.17) (P＜0.05).In Làt maze,number of rearing after intervention of both in SHRs(57.17 ± 5.67,60.83 ± 8.28,55.17 ± 9.45,65.33 ± 9.50 ) was less than saline control group(78.00 ± 13.84) (P＜0.05).Conclusion ABT-724 could improve behaviors of spontaneous locomotor activity,cognitive ability,non-selective attention in SHR.
