Therapeutic effect of three-dimensional conformal involved-field radiotherapy combined with chemotherapy on limited disease stage small cell lung cancer
10.3760/cma.j.issn.0254-5098.2011.05.016
- VernacularTitle:三维适形放射治疗联合化疗治疗局限期小细胞肺癌的疗效分析
- Author:
Guimei LIU
;
Guangrong XIA
;
Guohua JIN
;
Yongxiang XU
;
Xiaobo LI
;
Yunquan ZHANG
;
Wen HE
- Publication Type:Journal Article
- Keywords:
Small cell lung cancer;
3-dimensional conformal radiotherapy;
Chemotherapy;
Prognosis
- From:
Chinese Journal of Radiological Medicine and Protection
2011;31(5):567-570
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the therapeutic effect of three-dimensional conformal involvedfield radiotherapy (3D-CRT)combined with chemotherapy on limited disease stage small cell lung cancer (LD-SCLC).Methods The clinical data of 85 patients of LD-SCLC treated with 3D-CRT at the dose of 2 Gy/fraction,5 fractions per week for 5 - 7 weeks,with the median dose of 50 Gy ( 46 - 66 Gy),combined with 4 -8 cycles chemotherapy,64 males and 21 females,aged 29 -76,were collected and analyzed.Results The complete remission rate,partial remission rate,stability rate,and total effective rate were 36.5％,52.9％,10.6％,and 89.4％,respectively.The median survival time was 18 months,with the 1-,2-,and 3-year overall survival rates of 65.9％,33.8％,and 15.9％,respectively.The local recurrence rate,distant metastasis rate,and local recurrence + distant metastasis rate were 15.2％ (9/85),49.2％ (29/85),and 35.6％ (21/85),respectively.Body weight,response to therapy,cycles for chemotherapy,and concurrent chemo-radiotherapy were all independent prognostic factors for LD-SCLC.Cox muhivariable regression was used to analyze the prognostic factors.Conclusions Involved-field radiotherapy is effective for LD-SCLC.Distance metastasis is the main cause of treatment failure.
