Serum complement C3 and C4 levels for predicting severity of hepatic fibrosis in patients with chronic hepatitis B
10.3760/cma.j.issn.1674-2397.2011.05.011
- VernacularTitle:血清补体C3和C4在预测慢性乙型肝炎肝纤维化程度中的价值
- Author:
Zhanqing ZHANG
;
Wei LU
;
Yanbing WANG
;
Min RAO
;
Jie FENG
;
Yanling FENG
;
Fang SHEN
- Publication Type:Journal Article
- Keywords:
Chronic hepatitis B;
Hepatic fibrosis;
Complement;
ROC curve;
Non-invasive diagnosis
- From:
Chinese Journal of Clinical Infectious Diseases
2011;04(5):292-295
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the clinical value of serum complement C3 and C4 levels for predicting the severity of hepatic fibrosis in patients with chronic hepatitis B.MethodsHistopathological diagnosis was confirmed in 442 patients with chronic hepatitis B.Serum complement C3 and C4 levels were determined by Beckman-Coulter Immage 800 immunochemistry system.ROC curve was used to analyze the value of serum complement C3 and C4 levels in predicting the severity of hepatic fibrosis.ResultsThe areas under ROC curve of complement C3 and C4 for predicting significant fibrosis ( ≥ S2),severe fibrosis ( ≥ S3) and cirrhosis (S4) were all significantly larger than the area under diagonal reference line ( P =0.009,0.000,0.000 and P =0.005,0.000,0.000,respectively).According to ROC curves,the optimal cut-offs of serum complement G3 for predicting severe fibrosis and cirrhosis were ≤0.74 g/L and ≤0.64 g/L,and the corresponding sensitivity,specificity,positive predictive value,negative predictive value,accuracy were 0.585,0.681,0.617,0.650,0.636 and 0.509,0.775,0.423,0.830,0.710,respectively.The optimal cut-offs of serum complement C4 for predicting severe fibrosis and cirrhosis were ≤0.14 g/L and ≤0.12 g/L,and the corresponding sensitivity,specificity,positive predictive value,negative predictive value,accuracy were 0.565,0.634,0.576,0.623,0.602 and 0.463,0.781,0.407,0.818,0.704,respectively.ConclusionSerum complement C3 and C4 may be used for predicting severe fibrosis and cirrhosis in patients with chronic hepatitis B,but its stability and reliability need to be improved.
