Expression and significance of matrix metalloproteinase-2 and basic fibroblast growth factor in human glioma
10.3760/cma.j.issn.1673-4904.2011.29.011
- VernacularTitle:碱性成纤维细胞生长因子和基质金属蛋白酶2在脑胶质瘤中的表达及其意义
- Author:
Qiaochun HUANG
;
Guoping YANG
;
Junwu WEI
- Publication Type:Journal Article
- Keywords:
Glioma;
Fibroblast growth factors;
Matrix metalloproteinase-2
- From:
Chinese Journal of Postgraduates of Medicine
2011;34(29):32-34
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression and significance of matrix metalloproteinase-2 (MMP-2) and basic fibroblast growth factor (bFGF) in human glioma.Methods The expression levels of bFGF and MMP-2 in 56 cases of human glioma and 9 cases of normal brain tissue specimen were detected by immunohistochemistry technique.Furthermore,the correlation between the expression of the bFGF and MMP-2 was compared.Results In normal brain tissue,grade Ⅰ,Ⅱ and grade Ⅲ,Ⅳ,the positive expression of bFGF were (9.51 + 2.69)％,(24.78 ±- 7.57 )％,(41.23 ± 12.35 )％,respectively,and MMP-2were (7.18 ± 2.12)％,(21.56 ± 3.85 )％,(54.32 + 7.32)％,respectively.The differences were significant among them (P ＜0.05).bFGF and MMP-2 were positive correlated (r ＝0.71,P ＜0.01).Conclusions There is an intrinsic correlation between the expression of the bFGF and MMP-2 and histological grade of human gliomas.These findings suggest that the synergistic interaction of bFGF and MMP-2 play an important role during the tumor invasion.
