Clinical analysis of salivary concentration of carcinoembryonic antigen, interleukin-6,interleukin8 in oral squamous cell carcinoma

VernacularTitle:癌胚抗原、白细胞介素6及白细胞介素8在口腔鳞癌患者唾液中含量变化的临床分析
Author: Mingfang SHU
Publication Type:Journal Article
Keywords: Carcinoembryonic antigen; Interleukin-6; Interleukin-8; Oral squamous cell carcinoma
From: Chinese Journal of Postgraduates of Medicine 2011;34(30):19-21
CountryChina
Language:Chinese
Abstract: ObjectiveTo explore salivary concentration of carcinoembryonic antigen (CEA),interleukin (IL)-6,IL-8 in oral squamous cell carcinoma and its' clinical significance.MethodsForty-two cases with oral squamous cell carcinoma were selected as experience group and 50 healthy persons as control group.ELISA method was performed to detect CEA,IL-6,IL-8 level of salivary and serum in two groups.ResultsThe salivary concentration of CEA,IL-6 and IL-8 was (62.37 ± 20.80)μ g/L,(79.12 ± 30.26)ng/L,( 834.61 ± 231.85 ) ng/L respectively in experience group,(25.72 ± 12.65 ) μ g/L,(0.58 ± 0.25 ) ng/L,(209.71 ± 67.92) ng/L in control group.There was significant difference between two groups(P＜ 0.01 ).The serum concentration of CEA,IL-6 and IL-8 was(61.15 ± 23.69)μ g/L,(58.17 ± 12.83) ng/L,(852.31 ±172.97) ng/L respectively in experience group,and IL-6 level of serum were much lower than that of salivary (P ＜ 0.05).ConclusionsCEA,IL-6 and IL-8 can be biomarkers of oral squamous cell carcinoma.Salivary detection is an ideal auxiliary diagnosis method for its simplicity and sensitivity.