Treatment of malignant gliomas with stem cells mediated oncolytic adenovirus

VernacularTitle:干细胞介导溶瘤腺病毒治疗脑胶质瘤研究进展
Author: Chunhua YANG ; Lijun MAO
Publication Type:Journal Article
Keywords: Stem cells; Adenoviridae; Glioma
From: Journal of International Oncology 2011;38(11):833-835
CountryChina
Language:Chinese
Abstract: Oncolytic adenoviruses are genetically altered to replicate within tumor cella while exhibiting a high degree of infectivity,good safety and specificity.The use of oncolytic adenoviruses to treat malignant brain tumors has been proved to be a promising mode of cancer therapy.Local injection of adenoviral vectors fails to reach scattered infiltrative tumor cells within the brain parenchyma and the therapeutic effect of intracereberal injections of oncolytic adenoviruses is only seen in the vicinity of the injection site.To remedy this and prevent possible tumor recurrence,stem cells have been explored as vehicles for gene therapy in brain tumors given that they possess an intrinsic tropism for brain glioma.