Relevance between inflammatory factors and intradialytic hypertension in patients with maintenance hemodialysis
10.3760/cma.j.issn.1673-4904.2011.28.003
- VernacularTitle:炎性反应因子与维持性血液透析患者透析中高血压的相关性
- Author:
Xiurong LI
;
Xiaozhou HE
;
Jinfeng LIU
;
Liying MIU
;
Yan REN
- Publication Type:Journal Article
- Keywords:
Dialysis;
Hypertension;
C-reactive protein;
Interleukins;
Tumor necrosisfactor-alpha
- From:
Chinese Journal of Postgraduates of Medicine
2011;34(28):7-9
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between intradialytic hypertension (IDH) and inflammatory factors in patients with maintenance hemodialysis.Methods Forty maintenance hemodialysis patients were involved,including 20 patients with IDH (IDH group) and 20 patients without IDH(non-IDH group) during hemodialysis.All of them had no sign of acute infections or other progressive disease.The levels of C-reactive protein (CRP),interleukin (IL)-1 β,IL-6,tumor necrosis factor (TNF)-α were measured by enzyme-linked immunosorbent assay (ELISA) before hemodialysis and 1,2,4 h after hemodialysis.The correlation of hypertension to CRP,IL-1 β,IL-6,TNF-α was analyzed.Results The levels of CRP,IL-1β,IL-6,TNF-α were increased in IDH group with the progress of hemodialysis,but were stable innon-IDH group.Logistic regression analysis indicated that there were positive correlations between CRP (r =0.3652),IL-1β (r =0.3261 ),IL-6(r =03156),TNF- α (r =0.3324) and blood pressure during hemodialysis (P ＜ 0.01 ).Conclusion The levels of CRP,IL-1β,TNF-α,IL-6 are positively related to the IDH in maintenance hemodialysis patients.
