Effect of mild hypothermia on β2-microglobulin level in cerebrospinal fluid of traumatic brain injury patients
10.3760/cma.j.issn.1673-4203.2011.11.008
- VernacularTitle:亚低温对创伤性脑损伤患者脑脊液β2-微球蛋白的影响
- Author:
Liqing LIN
;
Xian FU
;
Jiandong WU
;
Qihua XIAO
;
Surong QIAN
;
Chenqiu WANG
;
Jianren WANG
;
Chen WANG
- Publication Type:Journal Article
- Keywords:
Brain injuries;
Mild hypothermia;
β2-microglobulin
- From:
International Journal of Surgery
2011;38(11):742-744
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of mild hypothermia on β2- microglobulin (MG) level in cerebrospinam(CSF) of traumatic brain injury (TBI) patients.Methods Thirty-six severe TBI patients were divided into two groups randomly,mild hypothermia treatment group and normathermia treatment group,and the β2- MG level and GOS score in CSF of these patients in different time- point were evaluated.Results β2-MG level increased at first,then decreased gradually,and MBP level in mild hypothermia group decreased greater than the control group( P ＜ 0.05 ),moreover,patients in mild hypothermia treatment group had better outcome than the control group( P ＜ 0.05).Conclusion Mild hypothermia may act as neuroprotection by inhibiting inflammatory response or improving immune regulation.
